Prof. Dr. Lenhard K. Rudolph

Funktionen

• Forschungsgruppenleiter "Stammzellenalterung: Wenn die Kräfte schwinden"

Forschungsgebiete

• Alterung
• Adulte Stammzellen
• DNA-Schädigung
• Tumorgenese
• chromosomale Instabilität
• Regeneration

Publikationen (ausgewählte 10 aktuelle)

1. Schwoerer, F. Becker, C. Feller, A. H. Baig, U. Koeber, H. Henze, J. M. Kraus, B. Xin, A. Lechel, D. B. Lipka, C. S. Varghese, M. Schmidt, R. Rohs, R. Aebersold, K. L. Medina, H. A. Kestler, F. Neri, J. von Maltzahn, S. Tuempel, K. L. Rudolph, "Epigenetic stress responses induce muscle stem cell aging by Hoxa9 developmental signals" Nature 2016, doi:10.1038/nature20603.
2. Tang, S. Tao, Z. Chen, I. O. Koliesnik, P. G. Calmes, V. Hoerr, B. Han, N. Gebert, M. Zörnig, B. Löffler, Y. Morita, K. L. Rudolph, "Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early aging", J. Exp. Med. 2016, 213, 535-553.
3. K. Meena, A. Cerutti, C. Beichler, Y. Morita, C. Bruhn, M. Kumar, J.M. Kraus, M.R. Speicher, Z. Q. Wang, H. A. Kestler, F. d'Adda di Fagagna, C. Günes, K. L. Rudolph. "Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion". EMBO J. 2015, 34, 1371-1384.
4. Tao, D. Tang, Y. Morita, T. Sperka, O. Omrani, A. Lechel, V. Sakk, J. Kraus, H. A. Kestler, M. Kühl, K. L. Rudolph, "Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage", EMBO J. 2015, 34, 624-640.
5.   Sperka, Z. Song, Y. Morita, K. Nalapareddy, L. M. Guachalla, A. Lechel, Y. Begus-Nahrmann, M. D. Burkhalter, M. Mach, F. Schlaudraff, B. Liss, Z. Ju, M. R. Speicher, K. L. Rudolph, "Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction", Nat. Cell Biol. 2011, 14, 73-79. 
6. Begus-Nahrmann, A. Lechel, A. C. Obenauf, K. Nalapareddy, E. Peit, E. Hoffmann, F. Schlaudraff, B. Liss, P. Schirmacher, H. Kestler, E. Danenberg, N. Barker, H. Clevers, M. R. Speicher, K. L. Rudolph, "p53 deletion impairs clearance of chromosomal instable stem cells in aging telomere dysfunctional mice", Nat. Genet. 2009, 41, 1138-1143.
7. A. Choudhury, Z. Ju, M. W. Djojosubroto, A. Schienke, A. Lechel, S. Schaetzlein, H. Jiang, A. Stepczynska, C. Wang, J. Buer, H. W. Lee, T. von Zglinicki, A. Ganser, P. Schirmacher, H. Nakauchi, K. L. Rudolph, "Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation", Nat. Genet. 2007, 39, 99-105.
8. Ju, H. Jiang, M. Jaworski, C. Rathinam, A. Gompf, C. Klein, A. Trumpp, K. L. Rudolph, "Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment", Nat. Med. 2007, 13, 742-747.
9. Schaetzlein, N. R. Kodandaramireddy, Z. Ju, A. Lechel, A. Stepzynska, D. R. Lilli, A. B. Clark, C. Rudolph, F. Kuhnel, K. Wei, B. Schlegelberger, P. Schirmacher, T. A. Kunkel, R. A. Greenberg, W. Edelmann, K. L. Rudolph, "Exo1 deletion impairs DNA damage signalling and prolongs lifespan of telomere dysfunctional mice", Cell 2007, 130, 863-877.
10. L. Rudolph, S. Chang, H. W. Lee, M. Blasco, G. J. Gottlieb, C. Greider, R. A. DePinho.  "Longevity, stress response and cancer in aging telomerase deficient mice." Cell 1999, 96, 701-712.