Dr. Paul Mike Jordan

Funktionen

• Wissenschaftlicher Mitarbeiter

Forschungsgebiete

• Rolle von Lipidmediatoren bei Entzündungen
• Entwicklung von dualen/multiplen Enzyminhibitoren
• Molekulare und zelluläre Mechanismen von Naturstoffen

Publikationen (ausgewählte 5 aktuelle)

1. Jordan PM, Werz O. Specialized pro-resolving mediators: biosynthesis and biological role in bacterial infections. FEBS J. 2022 Jul;289(14):4212-4227. doi: 10.1111/febs.16266. Epub 2021 Nov 18. PMID: 34741578.
2. Jordan PM, Gerstmeier J, Pace S, Bilancia R, Rao Z, Börner F, Miek L, Gutiérrez-Gutiérrez Ó, Arakandy V, Rossi A, Ialenti A, González-Estévez C, Löffler B, Tuchscherr L, Serhan CN, Werz O. Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution. Cell Rep. 2020 Oct 13;33(2):108247. doi: 10.1016/j.celrep.2020.108247. PMID: 33053344; PMCID: PMC7729929.
3. Jordan PM, Andreas N, Groth M, Wegner P, Weber F, Jäger U, Küchler C, Werz O, Serfling E, Kamradt T, Dudeck A, Drube S. ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids. Immunology. 2021 Nov;164(3):541-554. doi: 10.1111/imm.13386. Epub 2021 Jun 30. PMID: 34142370; PMCID: PMC8517600.
4. Jordan PM, van Goethem E, Müller AM, Hemmer K, Gavioli V, Baillif V, Burmeister Y, Krömmelbein N, Dubourdeau M, Seilheimer B, Werz O. The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators. Pharmaceuticals (Basel). 2021 Nov 3;14(11):1123. doi: 10.3390/ph14111123. PMID: 34832905; PMCID: PMC8623904.
5. Börner F, Pace S, Jordan PM, Gerstmeier J, Gomez M, Rossi A, Gilbert NC, Newcomer ME, Werz O. Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation. Adv Sci (Weinh). 2023 Feb;10(6):e2205604. doi: 10.1002/advs.202205604. Epub 2022 Dec 25. PMID: 36567268; PMCID: PMC9951388.