Prof. Dr. Thorsten Heinzel

Functions

• Professor for Biochemistry
• Director of the Institute of Biochemistry and Biophysics (CMB)

Research

• Mechanisms of transcriptional regulation
• Therapeutic applications of histone deacetylase inhibitors
• Regulation of cellular signaling pathways through protein acetylationublications (the 10 most important)

Publications (selected 5 most recent)

1. Kühne M, Kretzer C, Lindemann H, Godmann M, Heinze T, Werz O, Heinzel T (2021) Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation. Int. J. Pharmaceutics, 601:120567. DOI: 10.1016/j.ijpharm.2021.120567. Online ahead of print. PMID: 33812975.
2. Kühne M, Lindemann H, Grune C, Schröder D, Cseresnyés Z, Godmann M, Koschella A, Figge MT, Eggeling C, Fischer D, Heinze T, Heinzel T (2020) Biocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activity. J. Controlled Release, DOI: 10.1016/j.jconrel.2020.10.006.
3. Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, Imhof D, Christmann M, Heinzel T, Schneider G, Krämer OH (2018) HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. Nat Commun 9(1):764.
4. Krämer OH, Knauer SK, Greiner G, Jandt E, Reichardt S, Gührs KH, Stauber RH, Böhmer FB, Heinzel T (2009) A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev. 23: 223-235
5. Göttlicher M, Minucci S, Zhu P, Krämer OH, Schimpf A, Giavara S, Sleeman JP, LoCoco F, Nervi C, Pelicci PG, and Heinzel T (2001) Valproic acid defines a novel class of histone deacetylase inhibitors inducing differentiation of transformed and tumorigenic cells. EMBO J. 20: 6969-6978