Prof. Dr. Stefan Lorkowski

Stefan Lorkowski

Image: Stefan Lorkowski

Institute of Nutrition
Department of Biochemistry and Physiology of Nutrition
Dornburger Straße 25
07743 Jena
Phone: +49 3641 9 49 710
Fax:      +49 3641 9 49 712
stefan.lorkowski@uni-jena.de
Homepage de

Functions

  • Dept. of Biochemistry and Physiology of Nutrition
  • Head of the Thuringia section of the German Society for Nutrition e.V.
  • Coordinator of the competence cluster for nutrition and cardiovascular health (nutriCARD) Halle-Jena-Leipzig
  • Member of the steering group of the FSU profile line LIFE

Research

  • Transfection and transduction of monocytes and macrophages
  • Heterozygosity of monocytes and plasticity of macrophages
  • Molecular basis of atherosclerosis and inflammation
  • Nutritive modulation of lipid metabolism and cellular lipid metabolism / transport
  • Molecular mechanisms of action of nutritional constituents

Publications (selected 5 most recent)

  1. Schubert M, Kluge S, Brunner E, Pace S, Birringer M, Werz O, Lorkowski S. The α-tocopherol-derived long-chain metabolite α-13'-COOH mediates endotoxin tolerance and modulates the inflammatory response via MAPK and NFκB pathways. Free Radic Biol Med 2022; 178:83-96. DOI 10.1016/j.freeradbiomed.2021.11.032
  2. Willems S, Gellrich L, Chaikuad A, Kluge S, Werz O, Heering J, Knapp S, Lorkowski S, Schubert-Zsilavecz M, Merk D. Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions. Cell Chemical Biology 2021; 28(10):1489-1500. DOI 10.1016/j.chembiol.2021.04.019
  3. Hoff J, Karl B, Gerstmeier J, Beekmann U, Schmölz L, Börner F, Kralisch D, Bauer M, Werz O, Fischer D, Lorkowski S*, Press AT*. Controlled release of the α-tocopherol-derived metabolite α-13′-carboxychromanol from bacterial nanocellulose wound cover improves wound healing. Nanomaterials 2021; 11(8):1939. *Contributed equally. DOI 10.3390/nano11081939
  4. Wallert M, Bauer J, Kluge S, Schmölz L, Chen YC, Ziegler M, Searle AK, Maxones A, Schubert M, Thürmer M, Pein H, Koeberle A, Werz O, Birringer M, Peter K, Lorkowski S. The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenu-ates the inflammatory response. Redox Biology 2019; 24:101166.DOI 10.1016/j.redox.2019.101166
  5. Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig A, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A. Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase. Nature Communications 2018; 9(1):3834. DOI 10.1038/s41467-018-06158-5