Dr. Anja Träger

Functions

• Research Group Leader Parcticle Formulation Group (PFG)

Research

• Synthesis of polymer-based nanocarriers for gene delivery
• Structure-Property-Relationship of nanocarriers to evaluate stability, toxicity as well as efficiency
• Balancing active and passive targeting strategies for drug and gene delivery
• Transport of different genetic materials (siRNA, mRNA, DNA) for various applications, including therapy and biotechnology

Publications (selected 5 most recent)

1. J. I. Solomun, L. Martin, P. Mapfumo, E. Moek, E. Amro, F. Becker, S. Tuempel, S. Hoeppener, K. L. Rudolph, A. Traeger, “PH-Sensitive Packaging of Cationic Particles by an Anionic Block Copolymer Shell”, J. Nanobiotechnology 2022, 20, 336
2. P. Klemm, J. I. Solomun, M. Rodewald, M. T. Kuchenbrod, V. G. Hänsch, F. Richter, J. Popp, C. Hertweck, S. Hoeppener, C. Bonduelle, S. Lecommandoux, A. Traeger, S. Schubert “Polyplex Surfing as Efficient Gene Delivery Mechanism of Tailored Amphiphilic Polypeptides”  Biomacromolecules 2022, 23, 4718-4733
3. K. Leer, G. Cinar, J. I. Solomun, L. Martin, I. Nischang, A. Traeger, “Core-crosslinked, temperature- and pH-responsive micelles: Design, physicochemical characterization, and gene delivery application”, Nanoscale 2021, DOI: 10.1039/D1NR04223H
4. F. Richter, K. Leer, L. Martin, P. Mapfumo, J. I. Solomun, M. T. Kuchenbrod, S. Hoeppener, J. C. Brendel, A. Traeger, “The impact of anionic polymers on gene delivery: How composition and assembly help evading the toxicity-efficiency dilemma”, J. Nanobiotechnology 2021, 19, 292
5. A. T. Press, A. Traeger, C. Pietsch, A. Mosig, M. Wagner, M. G. Clemens, N. Jbeily, N. Koch, M. Gottschaldt, N. Beziere, V. Ermolayev, V. Ntziachristos, J. Popp, M. M. Kessels, B. Qualmann, U. S. Schubert, M. Bauer, "Cell type-specific delivery of short interfering rnas by dye-functionalised theranostic nanoparticles", Nat. Commun. 2014, 5, 5565