Prof. Dr. Oliver Werz
Institute of Pharmacy
Friedrich Schiller University Jena
Philosophenweg 14
07743 Jena
Phone: +49 3641 9 49 801
Fax: +49 3641 9 49 802
oliver.werz@uni-jena.de
Homepage de
Functions
- Chair holder of Pharmaceutical/Medicinal Chemistry
Research
- Pathobiochemistry of inflammation and inflammation-induced cancer
- Molecular and biochemical pharmacology of anti-inflammatory and antineoplastic agents
- Gender-specific Medicine and Pharmacology (Gender Medicine / GenderTailored Therapy)
- Target-oriented drug discovery and bioanalytical processing of drugs
- Target identification and target validation
- Natural substances as active ingredients
Publications (selected 10 most recent)
- Garscha, S. Voelker, S. Pace, J. Gerstmeier, B. Emini, S. Liening, A. Rossi, C. Weinigel, S. Rummler, U. S. Schubert, G. K. E. Scriba, E. Çelikoğlu, B. Çalışkan, E. Banoglu, L. Sautebin, O. Werz, "BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase / 5-lipoxygenase-activating protein (FLAP) complex assembly", Biochem. Pharmacol. 2016, 119, 17-26.
- Gerstmeier, C. Weinigel, S. Rummler, O. Rådmark, O. Werz, U. Garscha, "Time-resolved in situ assembly of the leukotriene-synthetic 5-LO / FLAP complex in blood leukocytes", FASEB J. 2016, 30, 276-285.
- Koeberle, C. Pergola, H. Shindou, S.C. Koeberle, T. Shimizu, S.A. Laufer, O. Werz, "Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis", FASEB J. 2015, 29, 2439-2449.
- Pergola, N. Gaboriaud-Kolar, N. Jestädt, S. König, M. Kritsanida, A. M. Schaible, H. Li, U. Garscha, C. Weinigel, D. Barz, K. F. Albring, O. Huber, A. L. Skaltsounis, O. Werz, "The indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase", J. Med. Chem. 2014, 57, 3715-3723.
- Reker, A. M. Perna, T. Rodrigues, P. Schneider, M. Reutlinger, B. Mönch, A. Koeberle, C. Lamers, M. Gabler, H. Steinmetz, R. Müller, M. Schubert-Zsilavecz, O. Werz, G. Schneider, "Revealing the macromolecular targets of complex natural products", Nat. Chem. 2014, 6, 1072-1078.
- Koeberle, E. Muñoz, G. B. Appendino, A. Minassi, S. Pace, A. Rossi, C. Weinigel, D. Barz, L. Sautebin, D. Caprioglio, J. A. Collado, O. Werz, "SAR studies on curcumin's pro-inflammatory targets: Discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase", J. Med. Chem. 2014, 57, 5638-5648.
- Krämer, T. Mentrup, B. Kleizen, E. Rivera-Milla, D. Reichenbach, C. Enzensperger, R. Nohl, E. Täuscher, H. Görls, A. Ploubidou, C. Englert, O. Werz, H. D. Arndt, C. Kaether, "Small molecules for intercepting Notch signaling and the early secretory pathway", Nat. Chem. Biol. 2013, 9, 731-738.
- Koeberle, H. Shindou, S. C. Koeberle, S. A. Laufer, T. Shimizu, O. Werz, "Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing Akt membrane binding", Proc. Natl. Acad. Sci. USA 2013, 110, 2546-2551.
- Koeberle, J. Romir, S. Fischer, A. Koeberle, V. Schattel, W. Albrecht, C. Grütter, O. Werz, D. Rauh, T. Stehle, S. Laufer, "Skepinone-L: A p38 mitogen activated protein kinase (MAPK) inhibitor with unsurpassed selectivity and outstanding in vivo efficiency", Nat. Chem. Biol. 2012, 8, 141-143.
- Pergola, G. Dodt, A. Rossi, E. Neunhoeffer, B. Lawrenz, H. Hinnak, B. Samuelsson, O. Rådmark, L. Sautebin, O. Werz, "ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma", Proc. Natl. Acad. Sci. USA 2008, 105, 19881-19886.