High-throughput method

By means of various synthesis robots libraries of polymers and (block) copolymers with graded property profiles (degree of polymerization, comonomer ratio, degree of crosslinking, block lengths, etc.) can be created specifically.

Formulation robots then allow further processing of the polymers, e.g. the reproducible production of nanoparticles or liposomal formulations.

Recent publications on the subject

K. W. Yang, J. T. Delaney, U. S. Schubert, A. Fahr, "Fast high-throughput screening of temoporfin-loaded liposomal formulations prepared by ethanol injection method", J. Liposome Res. 2012, 22, 31-41.

I. Y. Perevyazko, J. T. Delaney, A. Vollrath, G. M. Pavlov, S. Schubert, U. S. Schubert, "Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation", Soft Matter 2011, 7, 5030-5035.

L. I. Majoros, B. Dekeyser, N. Haucourt, P. Castelein, J. Paul, J. M. Kranenburg, E. Rettler, R. Hoogenboom, U. S. Schubert, "Preparation of polyurethane elastomers (PUEs) in a high-throughput workflow", J. Polym. Sci., Part A: Polym. Chem. 2011, 49, 301-313.

C. R. Becer, U. S. Schubert, "Parallel Optimization and High-Throughput Preparation of Well-Defined Copolymer Libraries Using Controlled/"Living" Polymerization Methods" in Polymer Libraries, Vol. 225, 2010, pp. 17-62.