Prof. Dr. Carsten Hoffmann

Prof. Dr. Carsten Hoffmann

Image: Prof. Dr. Carsten Hoffmann

Institute for Molecular Cell Biology
University Hospital Jena
Hans-Knöll-Str. 2
07745 Jena
Phone: + 49 3641 9 395 600
Fax:      + 49 3641 9 395 602
carsten.Hoffmann@med.uni-jena.de 
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Functions

  • Head of the Institute for Molecular Cell Biology of the University Hospital Jena
  • Head of the Masterprogramme "Molecular Medicine"
  • Member of the Interdisciplinary Center for Clinical Research (IZKF) and the Jena School of Molecular Medicine (JSMM) 
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Research

  • Activation and regulation mechanisms of G protein-coupled receptors
  • Microscopy of signal transduction of GPCRs in real time
  • Development of FRET and BRET sensors for the visualisation of cellular processes in signal transduction

Publications (selected 5 most recent)

  1. J. Drube, R.S. Haider, E.S.F. Matthees, M. Reichel, J. Zeiner, S. Fritzwanker, C. Ziegler, S. Barz, L. Klement, J. Filor, V. Weitzel, A. Kliewer, E. Miess-Tanneberg, E. Kostenis, S. Schulz, C. Hoffmann (2022) GPCR kinase knockout cells reveal the impact of individual GRKs on arrestin binding and GPCR regulation. Nature Communications, 13: 540, doi: 10.1038/s41467-022-28152-8. IF: 17.69
  2. R.S. Haider, E.S.F. Matthees, J. Drube, M. Reichel, U. Zabel, A. Inoue, A. Chevigne, C. Krasel, X. Deupi, C. Hoffmann (2022) β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells. IF: 17.69
  3. J. Grimes, Z. Koszegi, Y. Lanoiselée, T. Miljus, S.L. O’Brien, T.M. Stepniewski, B. Medel-Lacruz, M.Baidya, M. Makarova, R. Mistry, J. Goulding, J. Drube, C. Hoffmann, D.M. Owen, A.K. Shukla, J.Selent, S. J. Hill, D. Calebiro (2023) Plasma membrane preassociation drives β -arrestin coupling to receptors and activation. IF: 17.69
  4. T. Benkel, M. Zimmermann, J. Zeiner, S. Bravo, N. Merten, V. Lim, E.S.F Matthees, J. Drube, E. Miess-Tanneberg, D. Malan, M. Szpakowska, S. Monteleone, J. Grimes, Z. Koszegi, Y. Lanoiselée, S.O'Brien, N. Pavlaki, N. Dobberstein, A. Inoue, V. Nikolaev, D. Calebiro, A. Chevigne, P. Sasse, S.Schulz, C. Hoffmann, P. Kolb, M. Waldhoer, K. Simon, J. Gomeza, E. Kostenis (2022) How Carvedilol activates β2-adrenoceptors. IF: 6.548
  5. J. Kaufmann, N.K. Blum, F. Nagel, A. Schuler, J. Drube, C. Degenhart, J. Engel, J.  Eickhoff, P. Dasgupta, S. Fritzwanker, M. Guastadisegni, C. Schulte, E. Miess-Tanneberg, H.M. Maric, M. Spetea, A. Kliewer, M. Baumann, B. Klebl, R.K. Reinscheid, C. Hoffmann, S. Schulz (2022) A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening. IF: 17.69