Prof. Dr. Christina Ehrhardt

Functions

• Head of the Section for Experimental Virology (W2 professorship)
• Graduate School of Excellence (JSMC)

Research

• Pathogen-induced cellular signalling mechanisms with focus on viral respiratory pathogens (influenza viruses, respiratory syncytial viruses, rhinoviruses)
• Investigation of the pathogen-host interaction of viral and bacterial respiratory pathogens (e.g. Staphylococcus aureus) or fungi (e.g. Aspergillus fumigatus) in simple and complex infection models
• Investigation of cellular factors as targets for anti-pathogenic strategies

Publications (selected 5 most recent)

1. Jungwirth J, Häring C, König S, Giebeler L, Doshi H, Brandt C, Deinhardt-Emmer S, Löffler B, Ehrhardt C. 2022. D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir. Int J Mol Sci 23.

2. Deinhardt-Emmer S, Böttcher S, Häring C, Giebeler L, Henke A, Zell R, Jungwirth J, Jordan PM, Werz O, Hornung F, Brandt C, Marquet M, Mosig AS, Pletz MW, Schacke M, Rödel J, Heller R, Nietzsche S, Löffler B, Ehrhardt C. 2021. SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction. J Virol 95.

3. Deinhardt-Emmer S, Jäckel L, Häring C, Böttcher S, Wilden JJ, Glück B, Heller R, Schmidtke M, Koch M, Löffler B, Ludwig S, Ehrhardt C. 2021. Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice. Biomolecules 11.

4. Wilden JJ, van Krüchten A, Gieselmann L, Hrincius ER, Deinhardt-Emmer S, Haupt KF, Preugschas HF, Niemann S, Ludwig S, Ehrhardt C. 2020. The influenza replication blocking inhibitor LASAG does not sensitize human epithelial cells for bacterial infections. PLoS One 15:e0233052.

5. Preugschas HF, Hrincius ER, Mewis C, Tran GVQ, Ludwig S, Ehrhardt C. 2019. Late activation of the Raf/MEK/ERK pathway is required for translocation of the respiratory syncytial virus F protein to the plasma membrane and efficient viral replication. Cell Microbiol 21:e12955.