Prof. Dr. Hans-Dieter Arndt

Functions

• Vice Dean of the Faculty of Chemistry and Geosciences
• Director of the Institute of Organic Chemistry and Macromolecular Chemistry
• Chair holder Organic Chemistry I

Research

• Organic Synthetic Chemistry
• Natural and active substance research
• Chemical biology

Publications (selected 5 most recent)

1. S. Schoof, G. Pradel, M. N. Aminake, B. Ellinger, S. Baumann, M. Potowski, Y. Najajreh, M. Kirschner, H.-D. Arndt, "Anti-plasmodial thiostrepton derivatives are proteasome inhibitors with a dual mode of action", Angew. Chem. 2010, 122, 3389-3393; Angew. Chem. Int. Ed. 2010, 49, 3317-3321.
2. S. Basu, B. Ellinger, S. Rizzo, C. Deraeve, H.-D. Arndt, H. Waldmann, " Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small molecule activator of the Wnt-pathway", Proc. Natl. Acad. Sci. USA 2011, 108, 6805-6810.
3. H. Waldmann, T.-S. Hu, S. Renner, S. Menninger, R. Tannert, T. Oda, H.-D. Arndt, "Total synthesis of chondramide C and its binding mode to F-actin", Angew. Chem. 2008, 120, 6573-6577; Angew. Chem. Int. Ed. 2008, 47, 6473-6477.
4. S. Baumann, S. Schoof, S. D. Harkal, H.-D. Arndt, "Mapping the binding site of thiopeptide antibiotics by proximity induced covalent capture (PICC)", J. Am. Chem Soc. 2008, 130, 5664-5666.
5. M. Riedrich, S. D. Harkal, H.-D. Arndt, "Peptide-embedded heterocycles by mild single- and multiple aza-Wittig ring closures", Angew. Chem. 2007, 119, 2755-2758; Angew. Chem. Int. Ed. 2007, 46, 2701-2703.