Prof. Dr. Axel Brakhage
Leibniz-Institute for Natural Product Research and Infection Biology - "Hans-Knöll-Insititut" (HKI)
Beutenbergstraße 11a
07745 Jena
Phone: +49 3641 532 1001
Fax: +49 3641 532 0802
axel.brakhage@leibniz-hki-jena.de
HomepageExternal link
Functions
- Director Molecular and Applied Microbiology
- Head for Department
- Speaker SFB-Transregio "Pathogenic fungi and their human host: Networks of interaction"
Research
- Infection biology of human pathogenic fungi
- Molecular biotechnology / synthetic biotechnology of microbial compounds
- Microbial communication
- Eukaryotic gene regulation / transcription factors
Publications (selected 10 most recent)
- Bacher, F. Heinrich, U. Stervbo, M. Nienen, M. Vahldieck, C. Iwert, K. Vogt, J. Kollet, N. Babel, B. Sawitzki, C. Schwarz, S. Bereswill, M. M. Heimesaat, G. Heine, G. Gadermaier, C. Asam, M. Assenmacher, O. Kniemeyer, A. A. Brakhage, F. Ferreira, M. Wallner, M. Worm, A. Scheffold, "Regulatory T cell specificity directs tolerance versus allergy against aeroantigens in humans", Cell 2016, 167, 1067-1078.
- Weber, V. Valiante, C. S. Nødvig, D. J. Mattern, R. A. Slotkowski, U. H. Mortensen, A. A. Brakhage, "Functional reconstitution of a fungal natural product gene cluster by advanced genome editing", ACS Synth. Biol. 2016, DOI: 10.1021/acssynbio.6b00203.
- Gsaller, P. Hortschansky, T. Furukawa, P. D. Carr, B. Rash, J. Capilla, C. Müller, F. Bracher, O. Bowyer, H. Haas, A. A. Brakhage, M. J. Bromley, "Sterol biosynthesis and azole tolerance is governed by the opposing actions of SrbA and the CCAAT binding complex", PLoS Pathog. 2016, 12, e1005775.
- Akoumianaki, I. Kyrmizi, I. Valsecchi, M. S. Gresnigt, G. Samonis, E. Drakos, D. Boumpas, L. Muszkieta, M. C. Prevost, D. P. Kontoyiannis, T. Chavakis, M. G. Netea, F. L. van de Veerdonk, A. A. Brakhage, J. El-Benna, A. Beauvais, J. P. Latgé, G. Chamilos, "Aspergillus cell wall melanin blocks LC3-associated phagocytosis to promote pathogenicity", Cell Host Microbe 2016, 19, 79-90.
- Valiante, M. Cândida Monteiro, E. Mellado, N. El Aouad, J. R. Tormo, N. de Pedro, V. Gonzalez, O. Kniemeyer, J.-P. Latgé, A. Beauvais, F. Reyes, R. Altwasser, O. Genilloud, F. Vicente, A. A. Brakhage, "Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010)", Antimicrob. Agents Chemother. 2015, 59, 5145-5153.
- Hillmann, S. Novohradska, D. Mattern, T. Heinekamp, M. Westermann, T. Forberger, T. Winckler, A. A. Brakhage, "Virulence determinants of the human pathogenic fungus Aspergillus fumigatus protect against soil amoeba predation", Environ. Microbiol. 2015, 17, 2858-2869.
- Gsaller, P. Hortschansky, S. R. Beattie, V. Klammer, B. E. Lechner, N. Rietzschel, E. R. Werner, A. A. Vogan, D. Chung, U. Mühlenhoff, M. Kato, R. R. Cramer, A. A. Brakhage, H. Haas, "Aspergillus fumigatus HapX is a Janus transcription factor required for adaptation to both iron starvation and iron excess", EMBO J. 2014, 33, 2261-2276.
- A. Brakhage, "Regulation of fungal secondary metabolism", Nat. Rev. Microbiol. 2013, 11, 21-32.
- W. Nützmann, Y. Reyes-Dominguez, K. Scherlach, V. Schroeckh, F. Horn, A. Gacek, C. Hertweck, J. Strauss, A. A. Brakhage, "Bacteria induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada mediated histone acetylation", Proc. Natl. Acad. Sci. USA. 2011, 108, 14282-14287.
- Aimanianda, J. Bayry, S. Bozza, O. Kniemeyer, K. Perruccio, S. R. Elluru, C. Clavaud, S. Paris, A. A. Brakhage, S. V. Kaveri, L. Romani, J. P. Latge, "Surface hydrophobin prevents immune recognition of airborne fungal spores", Nature 2009, 460, 1117-1121.