Prof. Dr. Marc Thilo Figge

Functions

• Head of Department for Applied Systems Biology

Research

• Host-pathogen interaction on human pathogenic fungi
• Automated processing of microscopic images
• Spatiotemporal computer simulations of agent-based infection models

Publications (selected 10 most recent)

1. Pollmächer, S. Timme, S. Schuster, A. A. Brakhage, P. F. Zipfel, M. T. Figge, "Deciphering the counterplay of Aspergillus fumigatus infection and host inflammation by evolutionary games on graphs", Sci. Rep. 2016, 6, 27807.
2. Brandes, Z. Mokhtari, F. Essig, K. Hünniger, O. Kurzai, M. T. Figge, "Automated segmentation and tracking of non-rigid objects in time-lapse microscopy videos of polymorphonuclear neutrophils", Med. Image Anal. 2015, 20, 34-51.
3. Kraibooj, H. Schoeler, C. M. Svensson, A. A. Brakhage, M. T. Figge, "Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm", Frontiers Microbiol. 2015, 6, 549.
4. Lehnert, S. Timme, J. Pollmächer, K. Hünniger, O. Kurzai, M. T. Figge, "Bottom-up modeling approach for the quantitative estimation of parameters in pathogen-host interactions", Front. Microbiol. 2015, 6, 608.
5. Mech, D. Wilson, T. Lehnert, B. Hube, M. T. Figge, "Epithelial invasion outcompetes hypha development during Candida albicans infection as revealed by an image-based systems biology approach", Cytometry A 2014, 85, 126-139.
6. Hünniger, T. Lehnert, K. Bieber, R. Martin, M. T. Figge, O. Kurzai, "A virtual infection model quantifies innate effector mechanisms and Candida albicans immune escape in human blood", PLOS Comput. Biol. 2014, 10, e1003479.
7. Mokhtari, F. Mech, C. Zitzmann, M. Hasenberg, M. Gunzer, M. T. Figge, "Automated characterization and parameter-free classification of cell tracks based on local migration behavior", PLoS One 2013, 8, e80808.
8. Zang, S. Brandes, M. Tovar, K. Martin, F. Mech, P. Horbert, T. Henkel, M. T. Figge, M. Roth, "Real-time image processing for label-free enrichment of Actinobacteria cultivated in picolitre droplets", Lab Chip, 2013, 13, 3707-3713.
9. T. Figge, A. S. Reichert, M. Meyer-Hermann, H. D. Osiewacz, Deceleration of fusion-fission cycles improves mitochondrial quality control during aging", PLoS Comput. Biol. 2012, 8, e1002576.
10. T. Figge, A. Garin, M. Gunzer, M. Kosco-Vilbois, K. M. Toellner, M. Meyer-Hermann, "Deriving a germinal center lymphocyte migration model from two-photon data", J. Exp. Med. 2008, 205, 3019-3029.